HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-[3-(4-Hydroxyphenyl)propyl]imidazole → 2-Cyclohexyl-4-[4-[3-(1-imidazolyl)propyl]phenoxymethyl]oxazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-[3-(4-Hydroxyphenyl)propyl]imidazole | HCID 22009818 | — |
| Reactant | 4-(Chloromethyl)-2-cyclohexyl-1,3-oxazole | HCID 22241379 | — |
| Product | 2-Cyclohexyl-4-[4-[3-(1-imidazolyl)propyl]phenoxymethyl]oxazole | HCID 22009588 | 38% |
Reaction Steps
In substantially the same manner as in Working Example 48, 1-[3-(4-hydroxyphenyl)propyl]imidazole was allowed to react with 4-chloromethyl-2-cyclohexyloxazole to give 2-cyclohexyl-4-[4-[3-(1-imidazolyl)propyl]phenoxymethyl]oxazole. The yield was 38%. Recrystallization from ether-hexane gave colorless prisms, mp 46-47° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06211215B1 |
| Source dataset | uspto-grants-2001_04 |
| ORD ID | ord-b4515cc15a9c466dab6fd32dd30e8183 |
| Source note | uspto-grants-2001_04 |