HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-chloromethyl-2-[(E)-styryl]thiazole → 4-[4-[3-(1-imidazolyl)propyl]phenoxymethyl]-2-[(E)-2-phenylethenyl]thiazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-chloromethyl-2-[(E)-styryl]thiazole | HCID 22009735 | — |
| Reactant | 1-[3-(4-Hydroxyphenyl)propyl]imidazole | HCID 22009818 | — |
| Product | 4-[4-[3-(1-imidazolyl)propyl]phenoxymethyl]-2-[(E)-2-phenylethenyl]thiazole | HCID 22009844 | 58% |
Reaction Steps
In substantially the same manner as in Working Example 48, 1-[3-(4-hydroxyphenyl)propyl]imidazole was allowed to react with 4-chloromethyl-2-[(E)-2-phenylethenyl]thiazole to give 4-[4-[3-(1-imidazolyl)propyl]phenoxymethyl]-2-[(E)-2-phenylethenyl]thiazole. The yield was 58%. Recrystallization from ethyl acetate gave colorless prisms, mp 129-130° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06211215B1 |
| Source dataset | uspto-grants-2001_04 |
| ORD ID | ord-1508c70e71b04be593bc1bdc36a85574 |
| Source note | uspto-grants-2001_04 |