HCID 22009616, compound → HCID 22009748, compound

HRID 322385Notes

Reaction equation

HRID 322385 reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][CH2:10][N:11]2[CH:15]=[CH:14][N:13]=[CH:12]2)=[CH:4][CH:3]=1.Cl[CH2:17][C:18]1[CH:19]=[CH:20][C:21]2[O:25][C:24]([CH:26]([CH3:28])[CH3:27])=[N:23][C:22]=2[CH:29]=1>>[N:11]1([CH2:10][CH2:9][CH2:8][C:5]2[CH:6]=[CH:7][C:2]([O:1][CH2:17][C:18]3[CH:19]=[CH:20][C:21]4[O:25][C:24]([CH:26]([CH3:27])[CH3:28])=[N:23][C:22]=4[CH:29]=3)=[CH:3][CH:4]=2)[CH:15]=[CH:14][N:13]=[CH:12]1

Participants

3

Reactant 2

HCID 22009616HCID 22009616, compoundHCID 220098181-[3-(4-Hydroxyphenyl)propyl]imidazole

Product 1

HCID 22009748HCID 22009748, compoundYield 59%

Procedure

In substantially the same manner as in Working Example 48, 1-[3-(4-hydroxyphenyl)propyl]imidazole was allowed to react with 5-chloromethyl-2-isopropyl benzoxazole to give 5-[4-[3-(1-imidazolyl)propyl]phenoxymethyl]-2-isopropyl-benzoxazole. The yield was 59%. Recrystallization from ethyl acetate-hexane gave colorless prisms, mp 76-77° C.

Sources & evidence

ORD record
ord-521c1f88cb6d42a89a384a495a2a7bf3
Source dataset
uspto-grants-2001_04
Patent number
US06211215B1

Reaction notes

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