反应详情

To a solution of 4-[4-[3-(1-imidazolyl)propyl]-phenoxymethyl]-2-[(E)-2-phenylethenyl]oxazole (300 mg) in ethanol (100 ml) was added palladium-carbon (5%, wet, 300 mg). The mixture was subjected to catalytic hydrogenation at room temperature under atmospheric pressure. The catalyst was filtered off. The filtrate was concentrated to leave a crystalline product, which was recrystallized from ethyl acetate-hexane to give 4-[4-[3-(1-imidazolyl)propyl]phenoxymethyl]-2-(2-phenylethyl)oxazole (170 mg, 57%) as colorless prisms, mp 67-68° C.

1. customwas subjected to catalytic hydrogenation at room temperature under atmospheric pressure
2. filtrationThe catalyst was filtered off
3. concentrationThe filtrate was concentrated
4. customto leave a crystalline product, which
5. customwas recrystallized from ethyl acetate-hexane