HCID 22009737, compound → HCID 22009744, compound

HRID 322393Notes

Reaction equation

HRID 322393 reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][CH2:10][N:11]2[CH:15]=[CH:14][N:13]=[CH:12]2)=[CH:4][CH:3]=1.Cl[CH2:17][C:18]1[N:19]=[C:20]([CH:23]=[C:24]([C:31]2[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=2)[C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)[O:21][CH:22]=1>>[C:31]1([C:24]([C:25]2[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=2)=[CH:23][C:20]2[O:21][CH:22]=[C:18]([CH2:17][O:1][C:2]3[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][CH2:10][N:11]4[CH:15]=[CH:14][N:13]=[CH:12]4)=[CH:4][CH:3]=3)[N:19]=2)[CH:32]=[CH:33][CH:34]=[CH:35][CH:36]=1

Participants

3

Reactant 2

HCID 22009737HCID 22009737, compoundHCID 220098181-[3-(4-Hydroxyphenyl)propyl]imidazole

Product 1

HCID 22009744HCID 22009744, compoundYield 88%

Procedure

In substantially the same manner as in Working Example 47, 1-[3-(4-hydroxyphenyl)propyl]imidazole was allowed to react with 4-chloromethyl-2-(2,2-diphenyl ethenyl)oxazole to give 2-(2,2-diphenylethenyl)-4-[4-[3-(1-imidazolyl)propyl]phenoxymethyl]oxazole as an oily product. The yield was 88%.

Sources & evidence

ORD record
ord-36a500201b2c492c9245edd6229428fe
Source dataset
uspto-grants-2001_04
Patent number
US06211215B1

Reaction notes

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