HCID 22009682, compound → HCID 22009857, compound

HRID 322395Notes

Reaction equation

HRID 322395 reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][CH2:10][N:11]2[CH:15]=[CH:14][N:13]=[CH:12]2)=[CH:4][CH:3]=1.Cl[CH2:17][C:18]1[N:19]=[C:20](/[CH:23]=[CH:24]/[CH:25]2[CH2:30][CH2:29][CH2:28][CH2:27][CH2:26]2)[O:21][CH:22]=1>>[CH:25]1(/[CH:24]=[CH:23]/[C:20]2[O:21][CH:22]=[C:18]([CH2:17][O:1][C:2]3[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][CH2:10][N:11]4[CH:15]=[CH:14][N:13]=[CH:12]4)=[CH:4][CH:3]=3)[N:19]=2)[CH2:26][CH2:27][CH2:28][CH2:29][CH2:30]1

Participants

3

Reactant 2

HCID 22009682HCID 22009682, compoundHCID 220098181-[3-(4-Hydroxyphenyl)propyl]imidazole

Product 1

HCID 22009857HCID 22009857, compoundYield 67%

Procedure

In substantially the same manner as in Working Example 72, 1-[3-(4-hydroxyphenyl)propyl]imidazole was allowed to react with 4-chloromethyl-2-[(E)-2-cyclohexylethenyl]oxazole to give 2-[(E)-2-cyclohexylethenyl]-4-[4-[3-(1-imidazolyl)propyl]phenoxymethyl]oxazole. The yield was 67%. Recrystallization from isopropylether gave colorless prisms, mp 62-63° C.

Sources & evidence

ORD record
ord-0e86323bab614a63a29ebc59e08b469c
Source dataset
uspto-grants-2001_04
Patent number
US06211215B1

Reaction notes

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