HCID 11806574, compound → HCID 22009656, compound

HRID 322397Notes

Reaction equation

HRID 322397 reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][CH2:10][N:11]2[CH:15]=[CH:14][N:13]=[CH:12]2)=[CH:4][CH:3]=1.[O:16]1[C:20]2[CH:21]=[CH:22][CH:23]=[CH:24][C:19]=2[CH:18]=[C:17]1[C:25]1[O:26][CH:27]=[C:28]([CH2:30]Cl)[N:29]=1>>[O:16]1[C:20]2[CH:21]=[CH:22][CH:23]=[CH:24][C:19]=2[CH:18]=[C:17]1[C:25]1[O:26][CH:27]=[C:28]([CH2:30][O:1][C:2]2[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][CH2:10][N:11]3[CH:15]=[CH:14][N:13]=[CH:12]3)=[CH:4][CH:3]=2)[N:29]=1

Participants

3

Reactant 2

HCID 11806574HCID 11806574, compoundHCID 220098181-[3-(4-Hydroxyphenyl)propyl]imidazole

Product 1

HCID 22009656HCID 22009656, compoundYield 85%

Procedure

In substantially the same manner as in Working Example 72, 1-[3-(4-hydroxyphenyl)propyl]imidazole was allowed to react with 2-(2-benzofuranyl)-4-chloromethyl oxazole to give 2-(2-benzofuranyl)-4-[4-[3-(1-imidazolyl)propyl]phenoxymethyl]oxazole. The yield was 85%. Recrystallization from ethyl acetate-hexane gave colorless prisms, mp 122-123° C.

Sources & evidence

ORD record
ord-9958c01a368649188ff444ffce67d050
Source dataset
uspto-grants-2001_04
Patent number
US06211215B1

Reaction notes

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