HCID 22009725, compound → HCID 22009605, compound

HRID 322398Notes

Reaction equation

HRID 322398 reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][CH2:10][N:11]2[CH:15]=[CH:14][N:13]=[CH:12]2)=[CH:4][CH:3]=1.Cl[CH2:17][C:18]1[N:19]=[C:20]([C:23]2[CH:35]=[CH:34][C:33]3[C:32]4[C:27](=[CH:28][CH:29]=[CH:30][CH:31]=4)[C:26](=[O:36])[C:25]=3[CH:24]=2)[O:21][CH:22]=1>>[CH:24]1[C:25]2[C:26](=[O:36])[C:27]3[C:32](=[CH:31][CH:30]=[CH:29][CH:28]=3)[C:33]=2[CH:34]=[CH:35][C:23]=1[C:20]1[O:21][CH:22]=[C:18]([CH2:17][O:1][C:2]2[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][CH2:10][N:11]3[CH:15]=[CH:14][N:13]=[CH:12]3)=[CH:4][CH:3]=2)[N:19]=1

Participants

3

Reactant 2

HCID 22009725HCID 22009725, compoundHCID 220098181-[3-(4-Hydroxyphenyl)propyl]imidazole

Product 1

HCID 22009605HCID 22009605, compoundYield 86%

Procedure

In substantially the same manner as in Working Example 72, 1-[3-(4-hydroxyphenyl)propyl]imidazole was allowed to react with 4-chloromethyl-2-(9-fluorenone-2-yl)oxazole to give 2-(9-fluorenone-2-yl)-4-[4-[3-(1-imidazolyl)propyl]phenoxymethyl]oxazole. The yield was 86%. Recrystallization from ethanol gave yellow needles, mp 153-154° C.

Sources & evidence

ORD record
ord-53da68913a2d408b8b2add11e0e67df3
Source dataset
uspto-grants-2001_04
Patent number
US06211215B1

Reaction notes

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