HCID 22009760, compound → HCID 22009781, compound

HRID 322399Notes

Reaction equation

HRID 322399 reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][CH2:10][N:11]2[CH:15]=[CH:14][N:13]=[CH:12]2)=[CH:4][CH:3]=1.Cl[CH2:17][C:18]1[N:19]=[C:20]([CH:23]=[C:24]2[C:36]3[CH:35]=[CH:34][CH:33]=[CH:32][C:31]=3[C:30]3[C:25]2=[CH:26][CH:27]=[CH:28][CH:29]=3)[O:21][CH:22]=1>>[CH:26]1[C:25]2[C:24](=[CH:23][C:20]3[O:21][CH:22]=[C:18]([CH2:17][O:1][C:2]4[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][CH2:10][N:11]5[CH:15]=[CH:14][N:13]=[CH:12]5)=[CH:4][CH:3]=4)[N:19]=3)[C:36]3[C:31](=[CH:32][CH:33]=[CH:34][CH:35]=3)[C:30]=2[CH:29]=[CH:28][CH:27]=1

Participants

3

Reactant 2

HCID 22009760HCID 22009760, compoundHCID 220098181-[3-(4-Hydroxyphenyl)propyl]imidazole

Product 1

HCID 22009781HCID 22009781, compoundYield 84%

Procedure

In substantially the same manner as in Working Example 72, 1-[3-(4-hydroxyphenyl)propyl]imidazole was allowed to react with 4-chloromethyl-2-(9-fluorenylidene)methyloxazole to give 2-(9-fluorenylidenemethyl)-4-[4-[3-(1-imidazolyl)propyl]phenoxymethyl]oxazole. The yield was 84%. Recrystallization from ethyl acetate gave yellow prisms, mp 116-117° C.

Sources & evidence

ORD record
ord-a4ee57a77a744443a0e7c4f63ed661b3
Source dataset
uspto-grants-2001_04
Patent number
US06211215B1

Reaction notes

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