HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-[3-(4-Hydroxyphenyl)propyl]imidazole → 2-[4-[3-(1-Imidazolyl)propyl]phenoxymethyl]-5-phenylbenzoxazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-[3-(4-Hydroxyphenyl)propyl]imidazole | HCID 22009818 | — |
| Reactant | HCID 22064189 | HCID 22064189 | — |
| Product | 2-[4-[3-(1-Imidazolyl)propyl]phenoxymethyl]-5-phenylbenzoxazole | HCID 22009866 | 77% |
Reaction Steps
In substantially the same manner as in Working Example 72, 1-[3-(4-hydroxyphenyl)propyl]imidazole was allowed to react with 2-chloromethyl-5-phenylbenzoxazole to give 2-[4-[3-(1-imidazolyl)propyl]phenoxymethyl]-5-phenylbenzoxazole. The yield was 77%. Recrystallization from ethyl acetate-hexane gave pale yellow plates, mp 123-124° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06211215B1 |
| Source dataset | uspto-grants-2001_04 |
| ORD ID | ord-20642c78c99a4b7b8c0fd871d9c5b170 |
| Source note | uspto-grants-2001_04 |