1-[4-(4-Hydroxyphenyl)butyl]imidazole → HCID 22009843, compound

HRID 322401Notes

Reaction equation

HRID 322401 reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][CH2:10][CH2:11][N:12]2[CH:16]=[CH:15][N:14]=[CH:13]2)=[CH:4][CH:3]=1.Cl[CH2:18][C:19]1[CH:20]=[CH:21][C:22]2[O:26][C:25]([C:27]3[S:28][CH:29]=[CH:30][CH:31]=3)=[N:24][C:23]=2[CH:32]=1>>[N:12]1([CH2:11][CH2:10][CH2:9][CH2:8][C:5]2[CH:6]=[CH:7][C:2]([O:1][CH2:18][C:19]3[CH:20]=[CH:21][C:22]4[O:26][C:25]([C:27]5[S:28][CH:29]=[CH:30][CH:31]=5)=[N:24][C:23]=4[CH:32]=3)=[CH:3][CH:4]=2)[CH:16]=[CH:15][N:14]=[CH:13]1

Participants

3

Reactant 2

HCID 220096641-[4-(4-Hydroxyphenyl)butyl]imidazoleHCID 220097205-Chloromethyl-2-(2-thienyl)benzoxazole

Product 1

HCID 22009843HCID 22009843, compoundYield 81%

Procedure

In substantially the same manner as in Working Example 72, 1-[4-(4-hydroxyphenyl)butyl]imidazole was allowed to react with 5-chloromethyl-2-(2-thienyl)benzoxazole to give 5-[4-[4-(1-imidazolyl)butyl]phenoxymethyl]-2-(2-thienyl)benzoxazole. The yield was 81%. Recrystallization from ethyl acetate-hexane gave colorless prisms, mp 130-131° C.

Sources & evidence

ORD record
ord-28b794b112cb4a688948b1af554c54e8
Source dataset
uspto-grants-2001_04
Patent number
US06211215B1

Reaction notes

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