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4-(Chloromethyl)-2-(thiophen-2-yl)-1,3-oxazole → 4-[3-[3-(1-Imidazolyl)propyl]phenoxymethyl]-2-(2-thienyl)oxazole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-(Chloromethyl)-2-(thiophen-2-yl)-1,3-oxazole | HCID 2529531 | — |
| 反応物 | 1-[3-(3-Hydroxyphenyl)propyl]imidazole | HCID 22009809 | — |
| 生成物 | 4-[3-[3-(1-Imidazolyl)propyl]phenoxymethyl]-2-(2-thienyl)oxazole | HCID 22009800 | 78% |
反応手順
In substantially the same manner as in Working Example 72, 1-[3-(3-hydroxyphenyl)propyl]imidazole was allowed to react with 4-chloromethyl-2-(2-thienyl)oxazole to give 4-[3-[3-(1-imidazolyl)propyl]phenoxymethyl]-2-(2-thienyl)oxazole, oily substance. The yield was 78%.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06211215B1 |
| 出典データセット | uspto-grants-2001_04 |
| ORD ID | ord-438c560d72d544f8aaa185dace7518f4 |
| 出典メモ | uspto-grants-2001_04 |