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2-(4-Benzoylphenyl)-4-chloromethyloxazole → 2-(4-Benzoylphenyl)-4-[3-[3-(1-imidazolyl)propyl]phenoxymethyl]oxazole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-(4-Benzoylphenyl)-4-chloromethyloxazole | HCID 22009807 | — |
| 反応物 | 1-[3-(3-Hydroxyphenyl)propyl]imidazole | HCID 22009809 | — |
| 生成物 | 2-(4-Benzoylphenyl)-4-[3-[3-(1-imidazolyl)propyl]phenoxymethyl]oxazole | HCID 22009790 | 85% |
反応手順
In substantially the same manner as in Working Example 72, 1-[3-(3-hydroxyphenyl)propyl]imidazole was allowed to react with 2-(4-benzoylphenyl)-4-chloromethyloxazole to gave 2-(4-benzoylphenyl)-4-[3-[3-(1-imidazolyl)propyl]phenoxymethyl]oxazole. The yield was 85%. Recrystallization from ethyl acetate-hexane gave colorless prisms, mp 97-98° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06211215B1 |
| 出典データセット | uspto-grants-2001_04 |
| ORD ID | ord-86f23639e16b4be89e1959184e9540ee |
| 出典メモ | uspto-grants-2001_04 |