HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-[4-(3-Hydroxyphenyl)butyl]imidazole → 4-[3-[4-(1-imidazolyl)butyl]phenoxymethyl]-2-[(E)-2-phenylethenyl]oxazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-[4-(3-Hydroxyphenyl)butyl]imidazole | HCID 22009661 | — |
| Reactant | 4-Chloromethyl-2-styryl-oxazole | HCID 22009752 | — |
| Product | 4-[3-[4-(1-imidazolyl)butyl]phenoxymethyl]-2-[(E)-2-phenylethenyl]oxazole | HCID 22009776 | 70% |
Reaction Steps
In substantially the same manner as in Working Example 72, 1-[4-(3-hydroxyphenyl)butyl]imidazole was allowed to react with 4-chloromethyl-2-[(E)-2-phenylethenyl]oxazole to give 4-[3-[4-(1-imidazolyl)butyl]phenoxymethyl]-2-[(E)-2-phenylethenyl]oxazole. The yield was 70%. Recrystallization from ethyl acetate-hexane gave colorless prisms, mp 75-76° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06211215B1 |
| Source dataset | uspto-grants-2001_04 |
| ORD ID | ord-6c27999ea8ac42c58ec3af0bc12bf1c2 |
| Source note | uspto-grants-2001_04 |