1-[4-(3-Hydroxyphenyl)butyl]imidazole → 2-(4-Benzyloxyphenyl)-4-[3-[4-(1-imidazolyl)butyl]phenoxymethyl]oxazole

Participants

Role	Name	HCID	Charge
Reactant	1-[4-(3-Hydroxyphenyl)butyl]imidazole	HCID 22009661	—
Reactant	2-(4-Benzyloxy-phenyl)-4-chloromethyl-oxazole	HCID 22009845	—
Product	2-(4-Benzyloxyphenyl)-4-[3-[4-(1-imidazolyl)butyl]phenoxymethyl]oxazole	HCID 22009675	78%

Reaction Steps

In substantially the same manner as in Working Example 72, 1-[4-(3-hydroxyphenyl)butyl]imidazole was allowed to react with 2-(4-benzyloxyphenyl)-4-chloromethyloxazole to give 2-(4-benzyloxyphenyl)-4-[3-[4-(1-imidazolyl)butyl]phenoxymethyl]oxazole. The yield was 78%. Recrystallization from ethyl acetate-hexane gave colorless prisms, mp 87-88° C.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US06211215B1
Source dataset	uspto-grants-2001_04
ORD ID	ord-03c85665c5d446708c377b40e1b2cb77
Source note	uspto-grants-2001_04