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4-(Chloromethyl)-2-phenyl-1,3-oxazole → 4-[4-[4-(1-Imidazolyl)butyl]phenoxymethyl]-2-phenyloxazole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-(Chloromethyl)-2-phenyl-1,3-oxazole | HCID 3551196 | — |
| 反応物 | 1-[4-(4-Hydroxyphenyl)butyl]imidazole | HCID 22009664 | — |
| 生成物 | 4-[4-[4-(1-Imidazolyl)butyl]phenoxymethyl]-2-phenyloxazole | HCID 22009763 | 89% |
反応手順
In substantially the same manner as in Working Example 72, 1-[4-(4-hydroxyphenyl)butyl]imidazole was allowed to react with 4-chloromethyl-2-phenyloxazole to give 4-[4-[4-(1-imidazolyl)butyl]phenoxymethyl]-2-phenyloxazole. The yield was 89%. Recrystallization from ethyl acetate-hexane gave colorless prisms, mp 113-114° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06211215B1 |
| 出典データセット | uspto-grants-2001_04 |
| ORD ID | ord-5aa711f16bac4fe584b4bbafee5d3270 |
| 出典メモ | uspto-grants-2001_04 |