HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(Chloromethyl)-2-phenyl-1,3-oxazole → 4-[3-[3-(1-Imidazolyl)propyl]phenoxymethyl]-2-phenyloxazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(Chloromethyl)-2-phenyl-1,3-oxazole | HCID 3551196 | — |
| Reactant | 1-[3-(3-Hydroxyphenyl)propyl]imidazole | HCID 22009809 | — |
| Product | 4-[3-[3-(1-Imidazolyl)propyl]phenoxymethyl]-2-phenyloxazole | HCID 22009794 | 78% |
Reaction Steps
In substantially the same manner as in Working Example 72, 1-[3-(3-hydroxyphenyl)propyl]imidazole was allowed to react with 4-chloromethyl-2-phenyloxazole to give 4-[3-[3-(1-imidazolyl)propyl]phenoxymethyl]-2-phenyloxazole. The yield was 78%. Recrystallization from ethyl acetate-hexane gave colorless prisms, mp 62-63° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06211215B1 |
| Source dataset | uspto-grants-2001_04 |
| ORD ID | ord-ee5044c8a3364c0ea2967013ad80aeb4 |
| Source note | uspto-grants-2001_04 |