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5-Chloromethyl-2-(2-thienyl)benzoxazole → 5-[3-[3-(1-Imidazolyl)propyl]phenoxymethyl]-2-(2-thienyl)benzoxazole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 5-Chloromethyl-2-(2-thienyl)benzoxazole | HCID 22009720 | — |
| 反応物 | 1-[3-(3-Hydroxyphenyl)propyl]imidazole | HCID 22009809 | — |
| 生成物 | 5-[3-[3-(1-Imidazolyl)propyl]phenoxymethyl]-2-(2-thienyl)benzoxazole | HCID 22009785 | 76% |
反応手順
In substantially the same manner as in Working Example 72, 1-[3-(3-hydroxyphenyl)propyl]imidazole was allowed to react with 5-chloromethyl-2-(2-thienyl)benzoxazole to give 5-[3-[3-(1-imidazolyl)propyl]phenoxymethyl]-2-(2-thienyl)benzoxazole. The yield was 76%. Recrystallization from ethyl acetate-hexane gave colorless prisms, mp 86-87° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06211215B1 |
| 出典データセット | uspto-grants-2001_04 |
| ORD ID | ord-d55b1559c280404c9b9c9906b6d90cfb |
| 出典メモ | uspto-grants-2001_04 |