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1-[4-(3-Hydroxyphenyl)butyl]imidazole → HCID 22009687、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-[4-(3-Hydroxyphenyl)butyl]imidazole | HCID 22009661 | — |
| 反応物 | 5-Chloromethyl-2-(2-thienyl)benzoxazole | HCID 22009720 | — |
| 生成物 | HCID 22009687 | HCID 22009687 | 70% |
反応手順
In substantially the same manner as in Working Example 72, 1-[4-(3-hydroxyphenyl)butyl]imidazole was allowed to react with 5-chloromethyl-2-(2-thienyl)benzoxazole to give 5-[3-[4-(1-imidazolyl)butyl]phenoxymethyl]-2-(2-thienyl)benzoxazole. The yield was 70%. Recrystallization from ethyl acetate-hexane gave colorless prisms, mp 97-98° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06211215B1 |
| 出典データセット | uspto-grants-2001_04 |
| ORD ID | ord-d070bcd1c4a9497d8ba8cac2d29dda97 |
| 出典メモ | uspto-grants-2001_04 |