4-(Chloromethyl)-2-phenyl-1,3-thiazole → HCID 22009861, compound

HRID 322413Notes

Reaction equation

HRID 322413 reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][CH2:10][CH2:11][N:12]2[CH:16]=[CH:15][N:14]=[CH:13]2)=[CH:4][CH:3]=1.Cl[CH2:18][C:19]1[N:20]=[C:21]([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)[S:22][CH:23]=1>>[N:12]1([CH2:11][CH2:10][CH2:9][CH2:8][C:5]2[CH:6]=[CH:7][C:2]([O:1][CH2:18][C:19]3[N:20]=[C:21]([C:24]4[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=4)[S:22][CH:23]=3)=[CH:3][CH:4]=2)[CH:16]=[CH:15][N:14]=[CH:13]1

Participants

3

Reactant 2

HCID 2369694-(Chloromethyl)-2-phenyl-1,3-thiazoleHCID 220096641-[4-(4-Hydroxyphenyl)butyl]imidazole

Product 1

HCID 22009861HCID 22009861, compoundYield 91%

Procedure

In substantially the same manner as in Working Example 72, 1-[4-(4-hydroxyphenyl)butyl]imidazole was allowed to react with 4-chloromethyl-2-phenylthiazole to give 4-[4-[4-(1-imidazolyl)butyl]phenoxymethyl]-2-phenylthiazole. The yield was 91%. Recrystallization from ethyl acetate-hexane gave colorless prisms, mp 93-94° C.

Sources & evidence

ORD record
ord-26c8d8ca552c4991bd29b126482c6e9b
Source dataset
uspto-grants-2001_04
Patent number
US06211215B1

Reaction notes

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