HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(Chloromethyl)-2-phenyl-1,3-thiazole → 4-[3-[3-(1-Imidazolyl)propyl]phenoxymethyl]-2-phenylthiazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(Chloromethyl)-2-phenyl-1,3-thiazole | HCID 236969 | — |
| Reactant | 1-[3-(3-Hydroxyphenyl)propyl]imidazole | HCID 22009809 | — |
| Product | 4-[3-[3-(1-Imidazolyl)propyl]phenoxymethyl]-2-phenylthiazole | HCID 22009596 | 81% |
Reaction Steps
In substantially the same manner as in Working Example 72, 1-[3-(3-hydroxyphenyl)propyl]imidazole was allowed to react with 4-chloromethyl-2-phenylthiazole to give 4-[3-[3-(1-imidazolyl)propyl]phenoxymethyl]-2-phenylthiazole. The yield was 81%. Recrystallization from ethyl acetate-hexane gave colorless prisms, mp 63-64° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06211215B1 |
| Source dataset | uspto-grants-2001_04 |
| ORD ID | ord-a101a9a1a4ac440692d45f0865a967ea |
| Source note | uspto-grants-2001_04 |