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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 322416Generated: October 25, 2026

1-[3-(4-Hydroxyphenyl)propyl]imidazole → 4-[4-[3-(1-Imidazolyl)propyl]phenoxymethyl]-2-(3-methyl-2-thienyl)oxazole

https://huagongshe.com/reaction/322416

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-[3-(4-Hydroxyphenyl)propyl]imidazoleHCID 22009818—
Reactant4-Chloromethyl-2-(3-methyl-2-thienyl)oxazoleHCID 22009832—
Product4-[4-[3-(1-Imidazolyl)propyl]phenoxymethyl]-2-(3-methyl-2-thienyl)oxazoleHCID 2200970278%

Reaction Steps

In substantially the same manner as in Working Example 72, 1-[3-(4-hydroxyphenyl)propyl]imidazole was allowed to react with 4-chloromethyl-2-(3-methyl-2-thienyl)oxazole to give 4-[4-[3-(1-imidazolyl)propyl]phenoxymethyl]-2-(3-methyl-2-thienyl)oxazole. The yield was 78%. Recrystallization from ethyl acetate-hexane gave colorless prisms, mp 72-73° C.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06211215B1
Source datasetuspto-grants-2001_04
ORD IDord-af21ce97a14c420686ff378c9c133ddc
Source noteuspto-grants-2001_04