Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1-[4-(4-Hydroxyphenyl)butyl]imidazole → 2-(5-Bromo-4-methyl-2-thienyl)-4-[4-[4-(1-imidazolyl)butyl]phenoxymethyl]oxazole
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1-[4-(4-Hydroxyphenyl)butyl]imidazole | HCID 22009664 | — |
| 반응물 | 2-(5-Bromo-4-methyl-2-thienyl)-4-chloromethyloxazole | HCID 22009708 | — |
| 생성물 | 2-(5-Bromo-4-methyl-2-thienyl)-4-[4-[4-(1-imidazolyl)butyl]phenoxymethyl]oxazole | HCID 22009673 | 93% |
반응 단계
In substantially the same manner as in Working Example 72, 1-[4-(4-hydroxyphenyl)butyl]imidazole was allowed to react with 2-(5-bromo-4-methyl-2-thienyl)-4-chloromethyloxazole to give 2-(5-bromo-4-methyl-2-thienyl)-4-[4-[4-(1-imidazolyl)butyl]phenoxymethyl]oxazole. The yield was 93%. Recrystallization from ethyl acetate-hexane gave colorless prisms, mp 85-86° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06211215B1 |
| 출처 데이터셋 | uspto-grants-2001_04 |
| ORD ID | ord-76f27ee4d07343f491fa5c7a573e9adc |
| 출처 메모 | uspto-grants-2001_04 |