HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(Chloromethyl)-5-methyl-2-(thiophen-2-yl)-1,3-oxazole → 4-[4-[3-(1-Imidazolyl)propyl]phenoxymethyl]-5-methyl-2-(2-thienyl)oxazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(Chloromethyl)-5-methyl-2-(thiophen-2-yl)-1,3-oxazole | HCID 5076491 | — |
| Reactant | 1-[3-(4-Hydroxyphenyl)propyl]imidazole | HCID 22009818 | — |
| Product | 4-[4-[3-(1-Imidazolyl)propyl]phenoxymethyl]-5-methyl-2-(2-thienyl)oxazole | HCID 22009827 | 84% |
Reaction Steps
In substantially the same manner as in Working Example 72, 1-[3-(4-hydroxyphenyl)propyl]imidazole was allowed to react with 4-chloromethyl-5-methyl-2-(2-thienyl)oxazole to give 4-[4-[3-(1-imidazolyl)propyl]phenoxymethyl]-5-methyl-2-(2-thienyl)oxazole. The yield was 84%. Recrystallization from acetone-isopropyl ether gave colorless prisms, mp 102-103° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06211215B1 |
| Source dataset | uspto-grants-2001_04 |
| ORD ID | ord-476c6d2888394b5baff24aa2ba104266 |
| Source note | uspto-grants-2001_04 |