1-[3-(4-Hydroxyphenyl)propyl]imidazole → HCID 22009598, compound

HRID 322426Notes

Reaction equation

HRID 322426 reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][CH2:10][N:11]2[CH:15]=[CH:14][N:13]=[CH:12]2)=[CH:4][CH:3]=1.[Cl:16][C:17]1[O:21][C:20]([C:22]2[O:23][CH:24]=[C:25]([CH2:27]Cl)[N:26]=2)=[CH:19][CH:18]=1>>[Cl:16][C:17]1[O:21][C:20]([C:22]2[O:23][CH:24]=[C:25]([CH2:27][O:1][C:2]3[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][CH2:10][N:11]4[CH:15]=[CH:14][N:13]=[CH:12]4)=[CH:4][CH:3]=3)[N:26]=2)=[CH:19][CH:18]=1

Participants

3

Reactant 2

HCID 220098181-[3-(4-Hydroxyphenyl)propyl]imidazoleHCID 22009833HCID 22009833, compound

Product 1

HCID 22009598HCID 22009598, compoundYield 86%

Procedure

In substantially the same manner as in Working Example 72, 1-[3-(4-hydroxyphenyl)propyl]imidazole was allowed to react with 2-(5-chloro-2-furyl)-4-chloromethyloxazole to give 2-(5-chloro-2-furyl)-4-[4-[3-(1-imidazolyl)propyl]phenoxymethyl]oxazole. The yield was 86%. Recrystallization from ethyl acetate-isopropyl ether gave colorless prisms, mp 88-89° C.

Sources & evidence

ORD record
ord-851b17fb250d44b49bd821e72361763c
Source dataset
uspto-grants-2001_04
Patent number
US06211215B1

Reaction notes

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