HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Chloromethyl-2-(2-furyl)oxazole → 2-(2-Furyl)-4-[4-[3-(1-imidazolyl)propyl]phenoxymethyl]oxazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Chloromethyl-2-(2-furyl)oxazole | HCID 22009706 | — |
| Reactant | 1-[3-(4-Hydroxyphenyl)propyl]imidazole | HCID 22009818 | — |
| Product | 2-(2-Furyl)-4-[4-[3-(1-imidazolyl)propyl]phenoxymethyl]oxazole | HCID 22009821 | 31% |
Reaction Steps
In substantially the same manner as in Working Example 109, 1-[3-(4-hydroxyphenyl)propyl]imidazole was allowed to react with 4-chloromethyl-2-(2-furyl)oxazole to give 2-(2-furyl)-4-[4-[3-(1-imidazolyl)propyl]phenoxymethyl]oxazole. The yield was 31%. Recrystallization from ethyl acetate-hexane gave colorless prisms, mp 92-93° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06211215B1 |
| Source dataset | uspto-grants-2001_04 |
| ORD ID | ord-fdd8f8e2ef8d4e82af015f3fac9cc0f2 |
| Source note | uspto-grants-2001_04 |