HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(Chloromethyl)-1,3-benzoxazole → 2-[4-[3-(1-Imidazolyl)propyl]phenoxymethyl]benzoxazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(Chloromethyl)-1,3-benzoxazole | HCID 2061989 | — |
| Reactant | 1-[3-(4-Hydroxyphenyl)propyl]imidazole | HCID 22009818 | — |
| Product | 2-[4-[3-(1-Imidazolyl)propyl]phenoxymethyl]benzoxazole | HCID 22009846 | 28% |
Reaction Steps
In substantially the same manner as in Working Example 109, 1-[3-(4-hydroxyphenyl)propyl]imidazole was allowed to react with 2-chloromethylbenzoxazole to give 2-[4-[3-(1-imidazolyl)propyl]phenoxymethyl]benzoxazole. The yield was 28%. Recrystallization from ethyl acetate-hexane gave pale brown prisms, mp 81-82° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06211215B1 |
| Source dataset | uspto-grants-2001_04 |
| ORD ID | ord-e620bf2592c64184b709bbb1e703ba83 |
| Source note | uspto-grants-2001_04 |