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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 322434Generated: October 25, 2026

5-Chloromethyl-2-(2-thienyl)benzoxazole → 5-[4-[3-(1-Imidazolyl)propyl]phenoxymethyl]-2-(2-thienyl)benzoxazole

https://huagongshe.com/reaction/322434

Reaction equation

Participants

RoleNameHCIDCharge
Reactant5-Chloromethyl-2-(2-thienyl)benzoxazoleHCID 22009720—
Reactant1-[3-(4-Hydroxyphenyl)propyl]imidazoleHCID 22009818—
Product5-[4-[3-(1-Imidazolyl)propyl]phenoxymethyl]-2-(2-thienyl)benzoxazoleHCID 2200982053%

Reaction Steps

In substantially the same manner as in Working Example 109, 1-[3-(4-hydroxyphenyl)propyl]imidazole was allowed to react with 5-chloromethyl-2-(2-thienyl)benzoxazole to give 5-[4-[3-(1-imidazolyl)propyl]phenoxymethyl]-2-(2-thienyl)benzoxazole. The yield was 53%. Recrystallization from ethyl acetate-hexane gave colorless prisms, mp 130-131° C.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06211215B1
Source datasetuspto-grants-2001_04
ORD IDord-dd7b9fb6d81948a4bd7b4c5aff34dc6c
Source noteuspto-grants-2001_04