1-[3-(4-Hydroxyphenyl)propyl]imidazole → HCID 69557810, compound

HRID 322436Notes

Reaction equation

HRID 322436 reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][CH2:10][N:11]2[CH:15]=[CH:14][N:13]=[CH:12]2)=[CH:4][CH:3]=1.Cl[CH2:17][C:18]1[N:19]=[C:20]([C:23]2[S:24][C:25]3[CH:31]=[CH:30][C:29]([C:32]4[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=4)=[CH:28][C:26]=3[CH:27]=2)[O:21][CH:22]=1>>[N:11]1([CH2:10][CH2:9][CH2:8][C:5]2[CH:6]=[CH:7][C:2]([O:1][CH2:17][C:18]3[N:19]=[C:20]([C:23]4[S:24][C:25]5[CH:31]=[CH:30][C:29]([C:32]6[CH:33]=[CH:34][CH:35]=[CH:36][CH:37]=6)=[CH:28][C:26]=5[CH:27]=4)[O:21][CH:22]=3)=[CH:3][CH:4]=2)[CH:15]=[CH:14][N:13]=[CH:12]1

Participants

3

Reactant 2

HCID 220098181-[3-(4-Hydroxyphenyl)propyl]imidazoleHCID 54067978HCID 54067978, compound

Product 1

HCID 69557810HCID 69557810, compoundYield 67%

Procedure

In substantially the same manner as in Working Example 109, 1-[3-(4-hydroxyphenyl)propyl]imidazole was allowed to react with 4-chloromethyl-2-(5-phenyl-2-benzothienyl)oxazole to give 4-[4-[3-(1-imidazolyl)propyl]phenoxymethyl]-2-(5-phenyl-2-benzothienyl)oxazole. The yield was 67%. Recrystallization from ethyl acetate-hexane gave colorless prisms, mp 168-169° C.

Sources & evidence

ORD record
ord-20b25fb528404e00976ecb120a89dca5
Source dataset
uspto-grants-2001_04
Patent number
US06211215B1

Reaction notes

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