HCID 22009767, compound → HCID 22009615, compound

HRID 322439Notes

Reaction equation

HRID 322439 reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][CH2:10][N:11]2[CH:15]=[CH:14][N:13]=[CH:12]2)=[CH:4][CH:3]=1.Cl[CH2:17][C:18]1[CH:19]=[N:20][C:21]2[C:26]([CH:27]=1)=[CH:25][CH:24]=[C:23]([C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1)[CH:22]=2>>[N:11]1([CH2:10][CH2:9][CH2:8][C:5]2[CH:6]=[CH:7][C:2]([O:1][CH2:17][C:18]3[CH:19]=[N:20][C:21]4[C:26]([CH:27]=3)=[CH:25][CH:24]=[C:23]([C:28]3[CH:29]=[CH:30][CH:31]=[CH:32][CH:33]=3)[CH:22]=4)=[CH:3][CH:4]=2)[CH:15]=[CH:14][N:13]=[CH:12]1

Participants

3

Reactant 2

HCID 22009767HCID 22009767, compoundHCID 220098181-[3-(4-Hydroxyphenyl)propyl]imidazole

Product 1

HCID 22009615HCID 22009615, compoundYield 59%

Procedure

In substantially the same manner as in Working Example 109, 1-[3-(4-hydroxyphenyl)propyl]imidazole was allowed to react with 3-chloromethyl-7-phenylquinoline to give 3-[4-[3-(1-imidazolyl)propyl]phenoxymethyl]-7-phenylquinoline. The yield was 59%. Recrystallization from ethanol gave colorless prisms, mp 135-136° C.

Sources & evidence

ORD record
ord-06c9d25ef5e242ce8f420c36b7dc1119
Source dataset
uspto-grants-2001_04
Patent number
US06211215B1

Reaction notes

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