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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 322442Generated: October 31, 2026

1-[4-(4-Hydroxyphenyl)butyl]imidazole → 4-[4-[4-(1-Imidazolyl)butyl]phenoxymethyl]-2-(5-methyl-2-thienyl)oxazole

https://huagongshe.com/reaction/322442

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-[4-(4-Hydroxyphenyl)butyl]imidazoleHCID 22009664—
Reactant4-Chloromethyl-2-(5-methyl-2-thienyl)oxazoleHCID 22241454—
Product4-[4-[4-(1-Imidazolyl)butyl]phenoxymethyl]-2-(5-methyl-2-thienyl)oxazoleHCID 2200987265%

Reaction Steps

In substantially the same manner as in Working Example 109, 1-[4-(4-hydroxyphenyl)butyl]imidazole was allowed to react with 4-chloromethyl-2-(5-methyl-2-thienyl)oxazole to give 4-[4-[4-(1-imidazolyl)butyl]phenoxymethyl]-2-(5-methyl-2-thienyl)oxazole. The yield was 65%. Recrystallization from ethyl acetate-hexane gave colorless prisms, mp 82-83° C.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06211215B1
Source datasetuspto-grants-2001_04
ORD IDord-0ba8725bfc85434db0b80793628b7729
Source noteuspto-grants-2001_04