HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-[4-(4-Hydroxyphenyl)butyl]imidazole → 2-(4-Benzoylphenyl)-4-[4-[4-(1-imidazolyl)butyl]phenoxymethyl]oxazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-[4-(4-Hydroxyphenyl)butyl]imidazole | HCID 22009664 | — |
| Reactant | 2-(4-Benzoylphenyl)-4-chloromethyloxazole | HCID 22009807 | — |
| Product | 2-(4-Benzoylphenyl)-4-[4-[4-(1-imidazolyl)butyl]phenoxymethyl]oxazole | HCID 22009840 | 64% |
Reaction Steps
In substantially the same manner as in Working Example 109, 1-[4-(4-hydroxyphenyl)butyl]imidazole was allowed to react with 2-(4-benzoylphenyl)-4-chloromethyloxazole to give 2-(4-benzoylphenyl)-4-[4-[4-(1-imidazolyl)butyl]phenoxymethyl]oxazole. The yield was 64%. Recrystallization from ethyl acetate-hexane gave colorless prisms, mp 91-92° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06211215B1 |
| Source dataset | uspto-grants-2001_04 |
| ORD ID | ord-51d1684226c14e9e97f9d0f632c9d32c |
| Source note | uspto-grants-2001_04 |