HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chloro-5-[3-(1-imidazolyl)propyl]pyridine → 5-[3-(1-Imidazolyl)propyl]-2-[2-(2-thienyl)-4-oxazolylmethoxy]pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chloro-5-[3-(1-imidazolyl)propyl]pyridine | HCID 22009590 | — |
| Reactant | 2-(2-Thienyl)-4-oxazolylmethanol | HCID 22009775 | — |
| Product | 5-[3-(1-Imidazolyl)propyl]-2-[2-(2-thienyl)-4-oxazolylmethoxy]pyridine | HCID 22009632 | 67% |
Reaction Steps
In substantially the same manner as in Working Example 125, 2-(2-thienyl)-4-oxazolylmethanol was allowed to react with 2-chloro-5-[3-(1-imidazolyl)propyl]pyridine to give 5-[3-(1-imidazolyl)propyl]-2-[2-(2-thienyl)-4-oxazolylmethoxy]pyridine. The yield was 67%. Recrystallization from ethyl acetate-hexane gave brown prisms, mp 86-87° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06211215B1 |
| Source dataset | uspto-grants-2001_04 |
| ORD ID | ord-c065e9d170a44a66ba2867543e8d4b6a |
| Source note | uspto-grants-2001_04 |