HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phenylboronic Acid → 2-[4-[3-(1-Imidazolyl)propyl]phenoxymethyl]-6-phenylimidazo[1,2-a]pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phenylboronic Acid | HCID 66827 | — |
| Reactant | 6-Bromo-2-[4-[3-(1-imidazolyl)propyl]phenoxymethyl]imidazo[1,2-a]pyridine | HCID 22009851 | — |
| Product | 2-[4-[3-(1-Imidazolyl)propyl]phenoxymethyl]-6-phenylimidazo[1,2-a]pyridine | HCID 22009620 | 78% |
Reaction Steps
In substantially the same manner as in Working Example 135, 6-bromo-2-[4-[3-(1-imidazolyl)propyl]phenoxymethyl]imidazo[1,2-a]pyridine was allowed to react with phenylboronic acid to give 2-[4-[3-(1-imidazolyl)propyl]phenoxymethyl]-6-phenylimidazo[1,2-a]pyridine. The yield was 78%. Recrystallization from ethyl acetate-hexane gave colorless prisms, mp 106-107° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06211215B1 |
| Source dataset | uspto-grants-2001_04 |
| ORD ID | ord-14277a6973f04f6da702a2b804d6db6d |
| Source note | uspto-grants-2001_04 |