反应详情

A mixture of 2-(5-bromo-4-methyl-2-thienyl)-4-[4-[3-(1-imidazolyl)propyl]phenoxymethyl]oxazole (700 mg), zinc powder (200 mg), acetic acid (5 ml) and water (5 ml) was heated for 4 hours under reflux. The residue was filtered off, the filtrate was concentrated. To the residue was added ethyl acetate, washed with saturated aqueous sodium bicarbonate and water, dried (MgSO4), and concentrated under reduced pressure to give crystals of 4-[4-[3-(1-imidazolyl)propyl]phenoxymethyl]-2-(4-methyl-2-thienyl)oxazole (470 mg, 81%). Recrystallization from ethyl acetate-hexane gave colorless prisms, mp 077-178° C.

1. temperaturewas heated for 4 hours
2. temperatureunder reflux
3. filtrationThe residue was filtered off
4. concentrationthe filtrate was concentrated
5. additionTo the residue was added ethyl acetate
6. washwashed with saturated aqueous sodium bicarbonate and water
7. dry with materialdried (MgSO4)
8. concentrationconcentrated under reduced pressure