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2-(5-Bromo-4-methyl-2-thienyl)-4-[4-[4-(1-imidazolyl)butyl]phenoxymethyl]oxazole → 4-[4-[4-(1-Imidazolyl)butyl]phenoxymethyl]-2-(4-methyl-2-thienyl)oxazole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-(5-Bromo-4-methyl-2-thienyl)-4-[4-[4-(1-imidazolyl)butyl]phenoxymethyl]oxazole | HCID 22009673 | — |
| 触媒 | Zinc | HCID 23994 | — |
| 生成物 | 4-[4-[4-(1-Imidazolyl)butyl]phenoxymethyl]-2-(4-methyl-2-thienyl)oxazole | HCID 22009721 | 89% |
反応手順
In substantially the same manner as in Working Example 138, 2-(5-bromo-4-methyl-2-thienyl)-4-[4-[4-(1-imidazolyl)butyl]phenoxymethyl]oxazole was reduced by zinc powder to give 4-[4-[4-(1-imidazolyl)butyl]phenoxymethyl]-2-(4-methyl-2-thienyl)oxazole. The yield was 89%. Recrystallization from ethyl acetate-hexane gave colorless prisms, mp 77-78° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06211215B1 |
| 出典データセット | uspto-grants-2001_04 |
| ORD ID | ord-14fdd96524634192a24d56ce39ea3ebe |
| 出典メモ | uspto-grants-2001_04 |