HCID 22009585, compound → HCID 22009709, compound

HRID 322454Notes

Reaction equation

HRID 322454 reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][CH2:10][N:11]2[CH:15]=[CH:14][N:13]=[CH:12]2)=[CH:4][CH:3]=1.Cl[CH2:17][C:18]1[N:19]=[C:20]([C:23]2[S:24][CH:25]=[CH:26][C:27]=2[Cl:28])[O:21][CH:22]=1>>[Cl:28][C:27]1[CH:26]=[CH:25][S:24][C:23]=1[C:20]1[O:21][CH:22]=[C:18]([CH2:17][O:1][C:2]2[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][CH2:10][N:11]3[CH:15]=[CH:14][N:13]=[CH:12]3)=[CH:4][CH:3]=2)[N:19]=1

Participants

3

Reactant 2

HCID 22009585HCID 22009585, compoundHCID 220098181-[3-(4-Hydroxyphenyl)propyl]imidazole

Product 1

HCID 22009709HCID 22009709, compoundYield 77%

Procedure

In substantially the same manner as in Working Example 72, 1-[3-(4-hydroxyphenyl)propyl]imidazole was allowed to react with 4-chloromethyl-2-(3-chloro-2-thienyl)oxazole to give 2-(3-chloro-2-thienyl)-4-[4-[3-(1-imidazolyl)propyl]phenoxymethyl]oxazole. The yield was 77%. Recrystallization from ethyl acetate-hexane gave colorless prisms, mp 69-70° C.

Sources & evidence

ORD record
ord-def45037a19c460facce8d3cd4359840
Source dataset
uspto-grants-2001_04
Patent number
US06211215B1

Reaction notes

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