1-[4-(4-Hydroxyphenyl)butyl]imidazole → HCID 22009677, compound

HRID 322458Notes

Reaction equation

HRID 322458 reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][CH2:10][CH2:11][N:12]2[CH:16]=[CH:15][N:14]=[CH:13]2)=[CH:4][CH:3]=1.Cl[CH2:18][C:19]1[N:20]=[C:21]([C:24]2[O:25][C:26]([CH3:29])=[CH:27][CH:28]=2)[O:22][CH:23]=1>>[N:12]1([CH2:11][CH2:10][CH2:9][CH2:8][C:5]2[CH:6]=[CH:7][C:2]([O:1][CH2:18][C:19]3[N:20]=[C:21]([C:24]4[O:25][C:26]([CH3:29])=[CH:27][CH:28]=4)[O:22][CH:23]=3)=[CH:3][CH:4]=2)[CH:16]=[CH:15][N:14]=[CH:13]1

Participants

3

Reactant 2

HCID 220096641-[4-(4-Hydroxyphenyl)butyl]imidazoleHCID 22009666HCID 22009666, compound

Product 1

HCID 22009677HCID 22009677, compoundYield 99%

Procedure

In substantially the same manner as in Working Example 72, 1-[4-(4-hydroxyphenyl)butyl]imidazole was allowed to react with 4-chloromethyl-2-(5-methyl-2-furyl)oxazole to give 4-[4-[4-(1-imidazolyl)butyl]phenoxymethyl]-2-(5-methyl-2-furyl)oxazole. The yield was 99%. Recrystallization from ethyl acetate-hexane gave colorless prisms, mp 91-92° C.

Sources & evidence

ORD record
ord-8a4edb6050704ff6b2e2e816f7c41dcb
Source dataset
uspto-grants-2001_04
Patent number
US06211215B1

Reaction notes

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