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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 322461Generated: October 30, 2026

4-Chloromethyl-2-(5-cyano-2-thienyl)oxazole → 2-(5-Cyano-2-thienyl)-4-[4-[3-(1-imidazolyl)propyl]phenoxymethyl]oxazole

https://huagongshe.com/reaction/322461

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-Chloromethyl-2-(5-cyano-2-thienyl)oxazoleHCID 22009659—
Reactant1-[3-(4-Hydroxyphenyl)propyl]imidazoleHCID 22009818—
Product2-(5-Cyano-2-thienyl)-4-[4-[3-(1-imidazolyl)propyl]phenoxymethyl]oxazoleHCID 2200964170%

Reaction Steps

In substantially the same manner as in Working Example 72, 1-[3-(4-hydroxyphenyl)propyl]imidazole was reacted with 4-chlorometyl-2-(5-cyano-2-thienyl)oxazole to obtain 2-(5-cyano-2-thienyl)-4-[4-[3-(1-imidazolyl)propyl]phenoxymethyl]oxazole. The yield was 70%. Recrystallization from ethyl acetate-hexane gave colorless prisms, mp 73-74° C.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06211215B1
Source datasetuspto-grants-2001_04
ORD IDord-4b7e205ca4f24c7185cb17905c229291
Source noteuspto-grants-2001_04