HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(Chloromethyl)-2-(thiophen-2-yl)-1,3-oxazole → 4-[4-[3-(1-Imidazolyl)propyl]-2-methoxyphenoxymethyl]-2-(2-thienyl)oxazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(Chloromethyl)-2-(thiophen-2-yl)-1,3-oxazole | HCID 2529531 | — |
| Reactant | 1-[3-(4-Hydroxy-3-methoxyphenyl)propyl]imidazole | HCID 22009594 | — |
| Product | 4-[4-[3-(1-Imidazolyl)propyl]-2-methoxyphenoxymethyl]-2-(2-thienyl)oxazole | HCID 22009753 | 80% |
Reaction Steps
In substantially the same manner as in Working Example 72, 1-[3-(4-hydroxy-3-methoxyphenyl)propyl]imidazole was reacted with 4-chloromethyl-2-(2-thienyl)oxazole to obtain 4-[4-[3-(1-imidazolyl)propyl]-2-methoxyphenoxymethyl]-2-(2-thienyl)oxazole. The yield was 80%. Recrystallization from ethyl acetate-hexane gave colorless prisms, mp 94-95° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06211215B1 |
| Source dataset | uspto-grants-2001_04 |
| ORD ID | ord-05b10cec25384a0b8e5e2c737ca35ea7 |
| Source note | uspto-grants-2001_04 |