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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 322463Generated: October 27, 2026

1-[3-(4-Hydroxy-3-methoxyphenyl)propyl]imidazole → 4-[4-[3-(1-Imidazolyl)propyl]-2-methoxyphenoxymethyl]-2-(5-methyl-2-thienyl)oxazole

https://huagongshe.com/reaction/322463

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-[3-(4-Hydroxy-3-methoxyphenyl)propyl]imidazoleHCID 22009594—
Reactant4-Chloromethyl-2-(5-methyl-2-thienyl)oxazoleHCID 22241454—
Product4-[4-[3-(1-Imidazolyl)propyl]-2-methoxyphenoxymethyl]-2-(5-methyl-2-thienyl)oxazoleHCID 2200960172%

Reaction Steps

In substantially the same manner as in Working Example 72, 1-[3-(4-hydroxy-3-methoxyphenyl)propyl]imidazole was reacted with 4-chloromethyl-2-(5-methyl-2-thienyl)oxazole to obtain 4-[4-[3-(1-imidazolyl)propyl]-2-methoxyphenoxymethyl]-2-(5-methyl-2-thienyl)oxazole. The yield was 72%. Recrystallization from ethyl acetate-hexane gave colorless prisms, mp 92-93° C.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06211215B1
Source datasetuspto-grants-2001_04
ORD IDord-e276e38cee69408c8fe044a239077141
Source noteuspto-grants-2001_04