HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(Chloromethyl)-2-(thiophen-2-yl)-1,3-oxazole → 4-[2-Chloro-4-[3-(1-imidazolyl)propyl]phenoxymethyl]-2-(2-thienyl)oxazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(Chloromethyl)-2-(thiophen-2-yl)-1,3-oxazole | HCID 2529531 | — |
| Reactant | 1-[3-(3-Chloro-4-hydroxyphenyl)propyl]imidazole | HCID 22009875 | — |
| Product | 4-[2-Chloro-4-[3-(1-imidazolyl)propyl]phenoxymethyl]-2-(2-thienyl)oxazole | HCID 22009643 | 77% |
Reaction Steps
In substantially the same manner as in Working Example 72, 1-[3-(3-chloro-4-hydroxyphenyl)propyl]imidazole was reacted with 4-chloromethyl-2-(2-thienyl)oxazole to obtain 4-[2-chloro-4-[3-(1-imidazolyl)propyl]phenoxymethyl]-2-(2-thienyl)oxazole. The yield was 77%. Recrystallization from ethyl acetate-hexane gave colorless prisms, mp 93-94° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06211215B1 |
| Source dataset | uspto-grants-2001_04 |
| ORD ID | ord-221b0a892f9847e5a2fd8012911e071c |
| Source note | uspto-grants-2001_04 |