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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 322465Generated: October 27, 2026

1-[3-(3-Chloro-4-hydroxyphenyl)propyl]imidazole → 4-[2-Chloro-4-[3-(1-imidazolyl)propyl]phenoxymethyl]-2-(5-methyl-2-thienyl)oxazole

https://huagongshe.com/reaction/322465

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-[3-(3-Chloro-4-hydroxyphenyl)propyl]imidazoleHCID 22009875—
Reactant4-Chloromethyl-2-(5-methyl-2-thienyl)oxazoleHCID 22241454—
Product4-[2-Chloro-4-[3-(1-imidazolyl)propyl]phenoxymethyl]-2-(5-methyl-2-thienyl)oxazoleHCID 2200959383%

Reaction Steps

In substantially the same manner as in Working Example 72, 1-[3-(3-chloro-4-hydroxyphenyl)propyl]imidazole was reacted with 4-chloromethyl-2-(5-methyl-2-thienyl)oxazole to obtain 4-[2-chloro-4-[3-(1-imidazolyl)propyl]phenoxymethyl]-2-(5-methyl-2-thienyl)oxazole. The yield was 83%. Recrystallization from ethyl acetate-hexane gave colorless prisms, mp 95-96° C.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06211215B1
Source datasetuspto-grants-2001_04
ORD IDord-a850f78fa90541bba3f9d61cf783c027
Source noteuspto-grants-2001_04