HCID 22009694, compound → HCID 22009619, compound

HRID 322468Notes

Reaction equation

HRID 322468 reaction equation
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]1[O:7][CH:8]=[C:9]([CH2:11][CH2:12][CH2:13][OH:14])[N:10]=1.O[C:16]1[CH:21]=[CH:20][C:19]([CH2:22][CH2:23][CH2:24][N:25]2[CH:29]=[CH:28][N:27]=[CH:26]2)=[CH:18][CH:17]=1>>[N:25]1([CH2:24][CH2:23][CH2:22][C:19]2[CH:20]=[CH:21][C:16]([O:14][CH2:13][CH2:12][CH2:11][C:9]3[N:10]=[C:6]([C:2]4[S:1][CH:5]=[CH:4][CH:3]=4)[O:7][CH:8]=3)=[CH:17][CH:18]=2)[CH:29]=[CH:28][N:27]=[CH:26]1

Participants

3

Reactant 2

HCID 22009694HCID 22009694, compoundHCID 220098181-[3-(4-Hydroxyphenyl)propyl]imidazole

Product 1

HCID 22009619HCID 22009619, compoundYield 72%

Procedure

In substantially the same manner as in Working Example 146, 3-[2-(2-thienyl)-4-oxazolyl]propanol was mesylated and then reacted with 1-[3-(4-hydroxyphenyl)propyl]imidazole to obtain 4-[3-[4-[3-(1-imidazolyl)propyl]phenoxy]propyl]-2-(2-thienyl)oxazole. The yield was 72%. Recrystallization from ethyl acetate-hexane gave colorless prisms, mp 99-100° C.

Sources & evidence

ORD record
ord-2ef27311d1e047c9a7e5091df15eb9ec
Source dataset
uspto-grants-2001_04
Patent number
US06211215B1

Reaction notes

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