HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(2-Thienyl)-5-thiazolylmethanol → 5-[4-[4-(1-Imidazolyl)butyl]phenoxymethyl]-2-(2-thienyl)thiazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(2-Thienyl)-5-thiazolylmethanol | HCID 18673021 | — |
| Reactant | 1-[4-(4-Hydroxyphenyl)butyl]imidazole | HCID 22009664 | — |
| Product | 5-[4-[4-(1-Imidazolyl)butyl]phenoxymethyl]-2-(2-thienyl)thiazole | HCID 22009729 | 86% |
Reaction Steps
In substantially the same manner as in Working Example 159, 2-(2-thienyl)-5-thiazolylmethanol was chlorinated and then reacted with 1-[4-(4-hydroxyphenyl)butyl]imidazole to obtain 5-[4-[4-(1-imidazolyl)butyl]phenoxymethyl]-2-(2-thienyl)thiazole. The yield was 86%. Recrystallization from ethyl acetate-hexane gave pale yellow prisms, mp 128-129° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06211215B1 |
| Source dataset | uspto-grants-2001_04 |
| ORD ID | ord-67133c7c034b4b9eb7f50bc04c824b25 |
| Source note | uspto-grants-2001_04 |