反应详情

To a stirred solution of N-Boc 1,6-diaminohexane hydrochloride (1.51 g, 6 mmol) and triethyle amine (1.31 g, 13 mmol) in 50 mL methylene chloride was added 2-Nitrobenzenesulfonyl chloride (1.326 g, 6 mmol). The reaction mixture was stirred for 6 h at room temperature, quenched with brine, and extracted with methylene chloride (2×50 mL). The organic layer was washed with brine (a saturated solution of sodium chloride in water, unless otherwise specified), dried over anhydrous sodium sulfate, and concentrated in vacuo to yield the titled compound as yellow oil (2.1 g, 87%).

1. customquenched with brine
2. extractionextracted with methylene chloride (2×50 mL)
3. washThe organic layer was washed with brine (a saturated solution of sodium chloride in water
4. dry with materialdried over anhydrous sodium sulfate
5. concentrationconcentrated in vacuo