Sodium Hydroxide → HCID 22462212, compound

Participants

Reaction Steps

To a solution of 1,2,3,4-Tetrahydro-2-naphthalencarboxylic acid[6- (2-nitrobenzenesulfonylamino)-hexyl]-amide (0.54 g, 1.17 mmol) in 5 mL of glacial acetic acid stirred at 0° C. was added a solution of tin chloride (1.32 g, 5.88 mmol)in 5 mL conc. HCl and 1 mL of water. The reaction mixture was warmed to room temperature and stirred for 3 h and poured over crushed ice (50 g). The reaction mixture was neutralized with 10% sodium hydroxide and extracted with chloroform (5×50 mL), dried over sodium sulfate and concentrated to afford yellow oil (0.48 g, 95%).

Provenance & Evidence