HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → EtOAc EtOH H2O NH4OH
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | (2-Oxo-3-(2-(5,6,7,8-tetrahydro[1,8]-naphthyridin-2-yl)ethyl)pyrrolidin-1-yl)acetyl-3(S)-ethynyl-beta-alanine ethyl ester | HCID 86754778 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | EtOAc EtOH H2O NH4OH | HCID 86752451 | — |
| Product | (2-Oxo-3-(2-(5,6,7,8-tetrahydro[1,8]-naphthyridin-2-yl)ethyl)pyrrolidin-1-yl)acetyl-3(S)-ethynyl-beta-alanine | HCID 86754779 | — |
Reaction Steps
A mixture of 2-11 (0.1 g, 0.15 mmol), 1N NaOH (300 μL, and ethanol (1 mL) was stirred at ambient temperature for 1 hr. Concentration and then flash chromagraphy (silica, 25:10:1:1→15:10:1:1 EtOAc/EtOH/NH4OH/H2O) gave 2-13 as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06211184B1 |
| Source dataset | uspto-grants-2001_04 |
| ORD ID | ord-683b4928bb5d4e8fa7539d8d9774246f |
| Source note | uspto-grants-2001_04 |