HRID322506

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID14798

Sodium Hydroxide

HNaO

结构：CCOC(=O)C[C@H](NC(=O)CN1CCC(CCc2ccc3c(n2)NCCC3)C1=O)c1cccnc1

HCID86754780

未命名化合物

PRODUCTS

生成物

结构：O=C(O)C[C@H](NC(=O)CN1CCC(CCc2ccc3c(n2)NCCC3)C1=O)c1cccnc1

HCID44368757

未命名化合物

HCID86752451

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID702

Ethanol

C2H6O

PROCEDURE

实验过程

A mixture of 2-12 (0.1 g, 0.15 mmol), 1N NaOH (300 μL) and ethanol (1 mL) was stirred at ambient temperature for 1 hr. Concentration and the flash chromatography (silica, 25:10:1:1→15:10:1:1 EtOAc/EtOH/NH4OH/H2O) gave 2-14 as a white solid.

WORKUP

后处理

concentrationConcentration

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-4627002f9a8e4825846b426721e3f7f3
来源数据集: uspto-grants-2001_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06211184B1
来源说明: uspto-grants-2001_04

反应 SMILES

[CH2:1]([O:3][C:4](=[O:35])[CH2:5][C@@H:6]([C:29]1[CH:30]=[N:31][CH:32]=[CH:33][CH:34]=1)[NH:7][C:8](=[O:28])[CH2:9][N:10]1[CH2:14][CH2:13][CH:12]([CH2:15][CH2:16][C:17]2[CH:26]=[CH:25][C:24]3[CH2:23][CH2:22][CH2:21][NH:20][C:19]=3[N:18]=2)[C:11]1=[O:27])[CH3:2].[OH-:36].[Na+]>C(O)C>[CH3:2][CH2:1][O:3][C:4]([CH3:5])=[O:35].[CH3:2][CH2:1][OH:3].[NH4+:7].[OH-:36].[OH2:3].[O:27]=[C:11]1[CH:12]([CH2:15][CH2:16][C:17]2[CH:26]=[CH:25][C:24]3[CH2:23][CH2:22][CH2:21][NH:20][C:19]=3[N:18]=2)[CH2:13][CH2:14][N:10]1[CH2:9][C:8]([NH:7][C@H:6]([C:29]1[CH:30]=[N:31][CH:32]=[CH:33][CH:34]=1)[CH2:5][C:4]([OH:35])=[O:3])=[O:28]