HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanol → EtOAc EtOH H2O NH4OH
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Ethyl 2-oxo-3-[2-(5,6,7,8-tetrahydro-[1,8]naphthyridin-2-yl)ethyl]imidazolidin-1-yl-acetyl-3(S)-pyridin-3-yl-beta-alanine | HCID 86754783 | — |
| Product | EtOAc EtOH H2O NH4OH | HCID 86752451 | — |
| Product | 2-Oxo-3-[2-(5,6,7,8-tetrahydro-[1,8]naphthyridin-2-yl}ethyl]-imidazolidin-1-yl-acetyl-3-(S)-pyridin-3-yl-beta-alanine | HCID 86754782 | — |
Reaction Steps
A mixture of 6-11 (160 mg, 0.33 mmol), 1N NaOH (500 μL), and ethanol (1 mL) was stirred at ambient temperature for 1 hr, followed by concentration. Flash chromatography (silica, 25:10:1:1 to 15:10:1:1 EtOAc/EtOH/NH4OH/H2O) gave 6-12 as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06211184B1 |
| Source dataset | uspto-grants-2001_04 |
| ORD ID | ord-be5819c28a52451bb2e5e473c8522c3b |
| Source note | uspto-grants-2001_04 |